Histology of the Oxyphil (HŸrthle or Askenazy) Tumour

A variant follicular carcinoma is the oxyphil (Hurthle or Askenazy) tumour in which most of the neoplastic cells are large with bizarre- shaped nuclei and voluminous cytoplasm and which contain abundant eosinophilic granules (mitochondria) (Fig. 16.9). Oxyphil change may also be seen in papillary carcinomas, adenomas and, focally, in non-neoplastic thyroid parenchyma – particularly in autoimmune thyroiditis. 

See also:
• Autoimmune Thyroid disease and Hashimoto's Thyroiditis